Actigraphy assessment of motor activity and sleep in patients with alcohol withdrawal syndrome and the effects of intranasal oxytocin.

BACKGROUND AND AIMS:The alcohol withdrawal syndrome increases autonomic activation and stress in patients during detoxification, leading to alterations in motor activity and sleep irregularities. Intranasal oxytocin has been proposed as a possible treatment of acute alcohol withdrawal. The aim of the present study was to explore whether actigraphy could be used as a tool to register symptoms during alcohol detoxification, whether oxytocin affected actigraphy variables related to motor activity and sleep compared to placebo during detoxification, and whether actigraphy-recorded motor function during detoxification was different from that in healthy controls. METHODS:This study was a part of a randomized, double blind, placebo-controlled trial in which 40 patients with alcohol use disorder admitted for acute detoxification were included. Of these, 20 received insufflations with intranasal oxytocin and 20 received placebo. Outcomes were actigraphy-recorded motor activity during 5-hour sequences following the insufflations and a full 24-hour period, as well as actigraphy-recorded sleep. Results were related to clinical variables of alcohol intake and withdrawal, including self-reported sleep. Finally, the actigraphy results were compared to those in a group of 34 healthy individuals. RESULTS:There were no significant differences between the oxytocin group and the placebo group for any of actigraphy variables registered. Neither were there any correlations between actigraphy-recorded motor function and clinical symptoms of alcohol withdrawal, but there was a significant association between self-reported and actigraphy-recorded sleep. Compared to healthy controls, motor activity during alcohol withdrawal was lower in the evenings and showed increased variability. CONCLUSION:Intranasal oxytocin did not affect actigraphy-recorded motor activity nor sleep in patients with acute alcohol withdrawal. There were no findings indicating that actigraphy can be used to evaluate the degree of withdrawal symptoms during detoxification. However, patients undergoing acute alcohol withdrawal had a motor activity pattern different from than in healthy controls

Iterative calibration method for integrated tunable mmW vector-sum phase shifter

Abstract An iterative calibration method of 5G mmW vector- sum phase shifter (VSPS) is presented in this paper. The phase and amplitude imbalances of I and Q branches can be tuned. The phase is adjusted with a tunable polyphase filter (PPF) by changing its resonance frequency. The VSPS is equipped with differential amplifiers on each branch which are used to compensate for the amplitude imbalance. The iterative calibration method uses information collected during the measurements and adjusts VSPS parameters towards the optimal operation point. The error vector magnitude (EVM) of VSPS phase constellation decreases fast along the iterations, and the calibration process can be finished with a fraction of the measurement time compared with exhaustive search. Results show that the method can reach an RMS amplitude error of 0.11 dB and phase error of 0.6 degrees on selected frequency points

Indirect adaptive control of unknown diffusion equation

International audienceThis paper concerns the control of a diffusion equation with unknown or uncertain diffusivity. The purpose is to demonstrate the capabilities of adaptive control based on the identification of the unknown diffusion coefficient. This problem is similar to the control of flow with unknown Reynolds number which will be investigated in a future publication. The present version gives only the main ideas which will be fully detailed in the final version of the paper

Improving robust stability by increasing the number of controlled degrees of freedom

International audienc